منابع مشابه
Chemokines and cardiac fibrosis.
Several members of the chemokine family play an important role in reparative fibrosis and are involved in the pathogenesis of remodeling following myocardial infarction. Chemokines may regulate the fibrotic process through recruitment and activation of mononuclear cell subsets and fibroblast progenitors (fibrocytes), by exerting direct effects on resident fibroblasts, and by modulating angiogen...
متن کاملChemokines in liver inflammation and fibrosis.
Chemokines may be involved in the tissue response to injury regulating the influx of leukocytes, and modulating a number of other critical biologic actions, including angiogenesis, neoplastic growth, myo-fibroblast activation, and the response to viral infections. In the liver, up-regulated expression of different members of the chemokine system may be induced by almost all types of injury, and...
متن کاملTargeting the chemokines in myocardial inflammation.
The chemokines comprise a large family of small, highly basic proteins that play a critical role in basal and inflammatory leukocyte locomotion and trafficking.1,2 In addition to effects on cell locomotion, certain chemokines are capable of eliciting a variety of other responses affecting leukocyte adhesion, activation, and degranulation, mitogenesis, and apoptosis. Furthermore, chemokines have...
متن کاملBarriers and recent advances in non-viral vectors targeting the lungs for cystic fibrosis gene therapy
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in CFTR genes that affect chloride ion channel. The CF is a good nominee for gene therapy as the asymptomatic carriers are phenotypically normal, and the desired cells are accessible for vector delivery. Gene therapy shows promising effects involving the correction of gene or replacement of the mutant gene with the func...
متن کاملTargeting inflammation in cystic fibrosis.
disease, such as n –3 polyunsaturated fatty acids, receptor antagonists of the cysteinyl leukotrienes, macrolides, N acetylcysteine, and -1 antitrypsin have shown clinical efficacy or potential for clinical use, but to date no ideal anti-inflammatory agent for CF lung disease has been found [10] . Because of the notable side effects of broad-spectrum anti-inflammatory drugs, a more targeted app...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2009
ISSN: 1945-3477
DOI: 10.1038/scibx.2009.1062